- Major highways radiate from Jackson like spokes in a wheel. U.S. 70 and U.S. 412 provide east-west routes, while U.S. 45 and U.S. 45 Bypass go north and south. State routes include Highways 18, 198, and 223.
- Ten interchanges on Interstate 40 provide access to Madison County.
- Industrial parks are served with direct interchange access.